Journal: Frontiers in Immunology

Article Title: Inflammasome signaling proteins as biomarkers of COVID-19

doi: 10.3389/fimmu.2023.1014665

Figure Lengend Snippet: ROC of Inflammasome Biomarkers of active COVID-19 infection. ROC and AUC were calculated for each inflammasome signaling protein in the plasma of patients with an active COVID-19 infection (Positive) and healthy controls who never had a COVID-19 infection (Control). (A) Caspase-1: N: Control: 47, Positive: 29; (B) ASC: N: Control: 47, Positive: 29; (C) IL-1β: N: Control: 47, Positive: 29; and (D) IL-18: N: Control: 47, Positive: 29.

Article Snippet: JR and RWK are co-founders and managing members of InflamaCORE, LLC and have licensed patents on inflammasome proteins as biomarkers of injury and disease as well as on targeting inflammasome proteins for therapeutic purposes.

Techniques: Infection, Clinical Proteomics, Control

Journal: Frontiers in Immunology

Article Title: Inflammasome signaling proteins as biomarkers of COVID-19

doi: 10.3389/fimmu.2023.1014665

Figure Lengend Snippet: ROC of Inflammasome Biomarkers after recovery from COVID-19. ROC and AUC were calculated for each inflammasome signaling protein in the plasma of patients who recovered from an active COVID-19 infection (Positive) and healthy controls who never had a COVID-19 infection (Control). (A) Caspase-1: N: Control: 47, Recovered: 15; (B) ASC: N: Control: 47, Recovered: 16.

Article Snippet: JR and RWK are co-founders and managing members of InflamaCORE, LLC and have licensed patents on inflammasome proteins as biomarkers of injury and disease as well as on targeting inflammasome proteins for therapeutic purposes.

Techniques: Clinical Proteomics, Infection, Control

Journal: Frontiers in Immunology

Article Title: Inflammasome signaling proteins as biomarkers of COVID-19

doi: 10.3389/fimmu.2023.1014665

Figure Lengend Snippet: ROC Comparison among Inflammasome Biomarkers in COVID-19. (A) Correlation matrix using a Spearman correlation among biomarkers. (B) p-values of significance for the comparison among the biomarkers caspase-1, ASC, IL-1β and IL-18.

Article Snippet: JR and RWK are co-founders and managing members of InflamaCORE, LLC and have licensed patents on inflammasome proteins as biomarkers of injury and disease as well as on targeting inflammasome proteins for therapeutic purposes.

Techniques: Comparison

Journal:

Article Title: Comparative Proteomic Analysis of the Haemophilus ducreyi Porin-Deficient Mutant 35000HP::P2AB ▿

doi: 10.1128/JB.01487-08

Figure Lengend Snippet: Complete list of membrane-associated proteins identified by Protein Biomarker Discovery Service

Article Snippet: MP samples for the Protein Biomarker Discovery Service (ProtTech Inc., Norristown, PA) were isolated as described previously ( 46 ), with the following modification: protein samples were resuspended in a modified buffer Z containing 50 mM HEPES (final concentration) substituted for 50 mM Tris, pH 8.0 (final concentration), to prevent interference with the lysine residue acylation reaction.

Techniques: Membrane, Biomarker Discovery, Binding Assay, Solvent, Activity Assay, Modification

Journal: Expert review of precision medicine and drug development

Article Title: Tissue-based biomarkers in prostate cancer

doi: 10.1080/23808993.2017.1372687

Figure Lengend Snippet: Tissue-Based Prostate Cancer Tests

Article Snippet: In spite of these complexities, the PTEN/TMPRSS:ERG test (Metamark, Cambridge, MA, USA) is a commercially available assay.

Techniques: Methylation