Journal: Frontiers in Immunology

Article Title: Inflammasome signaling proteins as biomarkers of COVID-19

doi: 10.3389/fimmu.2023.1014665

Figure Lengend Snippet: ROC of Inflammasome Biomarkers of active COVID-19 infection. ROC and AUC were calculated for each inflammasome signaling protein in the plasma of patients with an active COVID-19 infection (Positive) and healthy controls who never had a COVID-19 infection (Control). (A) Caspase-1: N: Control: 47, Positive: 29; (B) ASC: N: Control: 47, Positive: 29; (C) IL-1β: N: Control: 47, Positive: 29; and (D) IL-18: N: Control: 47, Positive: 29.

Article Snippet: JR and RWK are co-founders and managing members of InflamaCORE, LLC and have licensed patents on inflammasome proteins as biomarkers of injury and disease as well as on targeting inflammasome proteins for therapeutic purposes.

Techniques: Infection, Clinical Proteomics, Control

Journal: Frontiers in Immunology

Article Title: Inflammasome signaling proteins as biomarkers of COVID-19

doi: 10.3389/fimmu.2023.1014665

Figure Lengend Snippet: ROC of Inflammasome Biomarkers after recovery from COVID-19. ROC and AUC were calculated for each inflammasome signaling protein in the plasma of patients who recovered from an active COVID-19 infection (Positive) and healthy controls who never had a COVID-19 infection (Control). (A) Caspase-1: N: Control: 47, Recovered: 15; (B) ASC: N: Control: 47, Recovered: 16.

Article Snippet: JR and RWK are co-founders and managing members of InflamaCORE, LLC and have licensed patents on inflammasome proteins as biomarkers of injury and disease as well as on targeting inflammasome proteins for therapeutic purposes.

Techniques: Clinical Proteomics, Infection, Control

Journal: Frontiers in Immunology

Article Title: Inflammasome signaling proteins as biomarkers of COVID-19

doi: 10.3389/fimmu.2023.1014665

Figure Lengend Snippet: ROC Comparison among Inflammasome Biomarkers in COVID-19. (A) Correlation matrix using a Spearman correlation among biomarkers. (B) p-values of significance for the comparison among the biomarkers caspase-1, ASC, IL-1β and IL-18.

Article Snippet: JR and RWK are co-founders and managing members of InflamaCORE, LLC and have licensed patents on inflammasome proteins as biomarkers of injury and disease as well as on targeting inflammasome proteins for therapeutic purposes.

Techniques: Comparison

Journal: BMJ Open Respiratory Research

Article Title: Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study

doi: 10.1136/bmjresp-2023-002219

Figure Lengend Snippet: Receiver operating characteristic curves for random forest classifier trained using clinical and imaging features plus protein biomarkers. Receiver operating characteristic curves for (A) performance of the random forest classifier trained using clinical/imaging features (age, gender, smoking status, pack-years and baseline interstitial features) plus the 20 protein biomarkers identified in the univariate screen, applied to the testing subset of COPDGene. (B) Performance of the random forest classifier trained using clinical/imaging features (age, gender, smoking status, pack-years and baseline interstitial features) plus the 11 protein biomarkers found in the multivariable confirmation step, applied to the testing subset of COPDGene. (C) Performance of the random forest classifier trained using clinical/imaging features (age, gender, smoking status, pack-years and baseline interstitial features) plus the four protein biomarkers found in the multivariable confirmation step in COPDGene that were available in PLuSS, applied to the testing subset of COPDGene. (D) Performance of the random forest classifier trained using clinical/imaging features (age, gender, smoking status, pack-years and baseline interstitial features) plus the four protein biomarkers found in the multivariable confirmation step in COPDGene that were available in PLuSS, applied to all available complete data in PLuSS. AUC, area under the curve; PLuSS, Pittsburgh Lung Screening Study.

Article Snippet: While they are both research cohorts, COPDGene involves visits at 5-year time points, imaging using standard dose CT scans and protein biomarkers measured using SOMAlogic.

Techniques: Imaging

Journal: BMJ Open Respiratory Research

Article Title: Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study

doi: 10.1136/bmjresp-2023-002219

Figure Lengend Snippet: Variable importance for incident interstitial features prediction models. (A) Variable importance for the random forest classifier trained using only clinical/imaging features. (B) Variable importance for the random forest classifier trained using clinical/imaging features plus the 20 protein biomarkers identified in the univariate screen. (C) Variable importance for the random forest classifier trained using clinical/imaging features plus the 11 protein biomarkers found in the multivariable confirmation step. (D) Variable importance for the random forest classifier trained using clinical/imaging features plus the four protein biomarkers found in the multivariable confirmation step in COPDGene that were available in PLuSS. PLuSS, Pittsburgh Lung Screening Study.

Article Snippet: While they are both research cohorts, COPDGene involves visits at 5-year time points, imaging using standard dose CT scans and protein biomarkers measured using SOMAlogic.

Techniques: Imaging

Journal: Reviews in Urology

Article Title: The Use of Biomarkers in Prostate Cancer Screening and Treatment

doi: 10.3909/riu0772

Figure Lengend Snippet: Summary of Available Tests and Indications

Article Snippet: PTEN/ TMPRSS2ERG (Metamark) , Biopsy , Presence or absence of PTEN deletion Presence or absence of TMRPRSS2ERG fusion , Cancer aggressive ness , Men with Gleason 3+3 or 3+ 4 on biopsy , Negative (intact PTEN, no ERG rearrangement): active surveillance Positive (PTEN deletion and/or ERG rearrangement): definitive treatment , Yoshimoto M et al 87.

Techniques: Expressing, Adjuvant

Journal: Translational Animal Science

Article Title: Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy Labrador Retrievers during an exercise regimen

doi: 10.1093/tas/txab084

Figure Lengend Snippet: Biomarker results between undenatured type II collagen (UC-II) and placebo treatment groups (Trx) during the first insult, at timepoints (TP) baseline, pre first 5 km run, and post first 5 km run and during the final insult at timepoints pre 16 km and post 16 km. Biomarkers evaluated were interleukin-6 (IL-6), creatine kinase-MM (CKM), and cartilage oligomeric matrix protein (COMP)

Article Snippet: Commercial biomarker kits were used for the analysis of interleukin-6 (#AB193686; Abcam; Burlingame, CA) (IL-6), creatine kinase-MM (#AB197749; Abcam; Burlingame, CA) (CKM), and cartilage oligomeric matrix protein (#MBS2123988; MyBiosource; San Diego, CA) (COMP).

Techniques: Biomarker Discovery